Categories
HIV

5th Generation HIV Test

This fifth generation test is the latest HIV screening test in to distinguish between HIV-1 antibodies, HIV-2 antibodies and the p24 antigen.

The 5th generation assay design simultaneously detects and reports:
• HIV Ag-Ab overall result
with
• HIV-1 p24 Ag
• HIV-1 Ab (groups M & O)
• HIV-2 Ab

The assay will have highly sensitive HIV-1 p24 antigen detection, Limit of Detection = 0.33 IU/mL and 5.2
pf/mL, for improved identification of HIV-1 acute infections.
· The assay also has improved earlier seroconversion detection compared to the 4th generation assay.

#The 5th generation test reduces the detection window period – the time between potential exposure and an accurate test result – to 10 to 14 days, leading to faster treatment as well as ability to control the spread of the disease

The 5th Generation HIV test provides more information than ever before about your HIV status. A major advance is that this test can now detect and identify both HIV-1 and HIV-2 antibodies and the p24 antigen individually in one blood sample, therefore specifically informing you which marker is positive.

By reporting on all three markers individually, if you test positive for any of the markers, it will mean that you can begin a more tailored treatment relevant to your needs much faster. The p24 antigen is detectable only in the early stages of an HIV infection, and the antibodies are the marker of a longer term established infection. By reporting on all of them, we can tell whether your HIV infection is more likely to be acute (or recent) or acquired more than three months ago.

HIV 1 and HIV 2 are two different viruses; HIV-1 is the more common virus worldwide, but they do both need different management. Medicines targeting HIV-1 will not usually be effective against the HIV-2 virus which is why it is important to know early on which viral type you have.

With over 33 million people now living with HIV globally, it is increasingly important to know your HIV status.

Note: 5th Generation HIV Test is a lab Test. As of today, there are no 5th Generation HIV Test Kit yet.

Categories
HIV

Common Adverse Effects of Antiretrovirals HIV Medications

Class
Drug Name
Common Adverse Effects
NRTI
Stavudine Nausea, vomiting, nerve pain, sunken face
Lamivudine Nausea, vomiting, headache, fatigue
Zidovudine Anemia, nausea, vomiting
Didanosine Headache, nausea, vomiting, diarrhea, nerve pain, sunken face
Tenofovir Rash, diarrhea, nausea, vomiting, kidney problems,
Abacavir Diarrhea, nausea, vomiting, liver problems
NNRTI
Nevirapine Rash, allergic reaction, hepatitis, headache, fatigue
Efavirenz Dizziness, nightmares, rash, insomnia, depression
PI
Indinavir Nausea, vomiting, increased bilirubin levels, kidney problems
Ritonavir Raised cholesterol levels, nausea, vomiting, altered sense of taste
Lopinavir Diarrhea, bloating, increased triglyceride and cholesterol levels, may cause or worsen diabetes
Darunavir Nausea, diarrhea, increased triglyceride and cholesterol levels, headache

Categories
HIV

When to Start Antiretroviral Therapy

NRTI
NNRTI
PI
Stavudine Nevirapine (Hirapine ®) Indinavir (Crixivan ®)
Lamivudine (3TC ®) Efavirenz (Stocrin ®) Ritonavir (Norvir ®)
Zidovudine (Retrovir ®) Lopinavir (Kaletra ®)
Didanosine (Dinex EC ®) Darunavir (Prezista ®)
Tenofovir (Tenvir ®)
Abacavir (Ziagen ®)

HAART is started when CD4 cell counts are less than 350cells/mm³. CD4 is a laboratory marker that is used to assess one’s immune status, with a normal CD4 counts to be between 500-1000 cells/mm³. Evidence states that there is a higher likehood of CD4 normalisation if HAART is initiated earlier.

The first line treatment consists of 2 drugs from the NRTI group and 1 drug from the NNRTI group. This set of medications will be supplied by the Ministry of Health for life if patients are successfully treated on the first line treatment. Second-line treatment consists of 2 NRTIs and 2 PIs, but one of the PI drugs will have to be purchased by the patient, whilst the remaining medications will be supplied by the Ministry of Health.

The selection of the antiretroviral regimen is based on several factors including comorbid conditions such as cardiovascular disease, liver disease or tuberculosis, pregnancy, potential drug interactions, gender, baseline CD4 counts and patient adherence potential.

Categories
HIV

HIV Medication in Malaysia

Infection with Human Immunodefi ciency Virus (HIV) leads to progressive immune destruction as a result
of persistent viral replication. Antiretroviral therapy has been shown to decrease viral replication, increase
CD4+ T-cell count, decrease the frequency of opportunistic infections, improve quality of life and prolong
life expectancy of HIV infected patients.

Although the concept of actual eradication remains speculative at this time, significant progress in
antiretroviral therapy has brought forth the concept of HIV infection as a chronic, manageable condition.
In Malaysia, there are 6 groups of antiretroviral agents that are available:

Antiretroviral Drugs Available in the Ministry of Health, Malaysia

1. Nucleoside Reverse Transcriptase Inhibitors(NRTI)/Nucleotide Reverse Transcriptase
Inhibitors (ntRTI)
a. Zidovudine (AZT) (Retrovir ®)
b. Didanosine buffered(ddI) or enteric coated(ddI EC) (Dinex EC ®)
c. Stavudine (d4T)
d. Lamivudine (3TC)
e. Abacavir (ABC) (Ziagen ®)
f. Tenofovir (TDF) (Tenvir ®)
g. Emtricitabine (FTC) (available as combination with tenofovir)

2. Non Nucleoside Reverse Transcriptase Inhibitor (NNRTI)
a. Nevirapine (NVP) (Hirapine ®)
b. Efavirenz (EFV) (Stocrin ®)
c. Etravirine (Intelence)

3. Protease Inhibitors (PI)
a. Indinavir (IDV) (Crixivan ®)
b. Lopinavir/ritonavir (Kaletra) (Kaletra ®)
c. Saquinavir
d. Atazanavir (ATV)
e. Darunavir (Prezista) (Prezista ®)
f. Ritonavir (Crixivan ®)
g. Nelfi navir (Viracept)

4. Integrase Inhibitors
a. Raltegravir (Isentress)

5. CCR5 Antagonists
a. Maraviroc (Celsentri)

6. Fusion Inhibitor
a. Enfuritide (Fuzeon)

Categories
Uncategorized

Hair Drug Testing

Beginning 2018,

Beginning 2018. The method of using hair samples to detect drug usage among those who want to join the Royal Malaysia Police (PDRM) will be implemented this year …Not only that, employers are now using Hair Drug Testing in Malaysia.

Hair Drug Tests Are Now the Norm

In Malaysia, the hair drug test is gaining favor over older and more frequently used urine and blood tests for three reasons:

  1. Hair tests detect a much longer history of drug use: Hair stores a longer history of drug use than either urine or blood, which are limited to days for most drug types.
  2. Hair tests are harder to cheat: there are no privacy issues with removing a hair sample from a person’s head, so the sample can be taken in full view.
  3. Older tests are losing effectiveness: urine testing has become less reliable due to the proliferation of cheat products like synthetic urine and powders.

 

How The Hair Drug Test Works

The reason a hair follicle test works is simple: your hair needs blood to grow, and it gets that blood via the root of the hair follicle.

When you use drugs, traces of the drug are deposited directly from your bloodstream into and onto the hair shaft, via the hair follicle. Either the drug itself is deposited, or your body may react to a drug by producing metabolites, which are then deposited onto and into your hair.

As your hair grows over time, the chemicals that are deposited onto your hair store a record of your drug use, sort of like the rings of a tree record the changing of the seasons.

 

 

WHAT HAPPENS DURING THE TEST

Only a small sample of hair will be cut from the top or back of your scalp right at the skin line and placed into a sealed container/envelope.

You can either cut yourself (by viewing video on how to cut your hair) and send to us via courier. And we will do the rest. Just sit back and we will send you the results via email. As Simple as That.

Whatsapp us 016 982 0330 to get a tutorial on how to cut your hair properly.

Results will be email to you after one week.

More video here https://youtu.be/ibVy5vmv908

 

WE TEST FOR MORE THAN 28 DRUG SUBSTANCES.

YES 28 Drug Substances..for ONLY RM650 (Normal price RM700)

1.Amphetamine
2.Phentermine
3.Methamphetamine
4.Nicotine
5.Methylenedioxyamphetamine (MDA)
6.Methylenedioxy-methamphetamine (MDMA)
7.Methylenedioxy-methamphetamine (MDEA)
8.Meperidine
9.Phencyclidine
10.Methadone
11.Cocaine
12.Profiden (SKF-525a)
13.Oxsepam
14.Codeine
15,Lorazepam
16.Diazepam
17.Hydrocodone
18.Tetrahydrocannabiol
19.Oxycodone
20.Temazepam
21.Flunitrazepam
22.Diacetylmorphine (Heroin)
23.Nitrazepam
24.Clonazepam
25.Alprazolam
26.Varapamil
27.Strychnine
29.Tracodone

You can add Ketamine too. let us know what you require.

Note: 

The hair follicle drug test was originally designed to detect heavy long-term drug users, not occasional pot smokers. For short-term testing, employers and labs still use urine test.

A hair test can detect drug use for up to 12 prior months, but accurate results are typically limited to the past 90 days. In contrast, urine and blood tests cannot test for use further back than a few days. This is why a lot of employers prefer the hair follicle test.

 

Becareful not to cut too much hair on one spot to avoid bald area like this woman, you can take hair from all over your head area. Or if you’re “Botak” Bald, then Any hair on your body can be used for any hair drug test for example arm pit hair, pubic hair, any part of your body hair and it should double the amount because body hair is more fine than hair on your head.

https://www.thedenverchannel.com/news/local-news/denver-woman-says-lab-tech-took-too-much-hair-for-follicle-drug-test-left-her-with-big-bald-spot

 

 

 

 

Categories
Uncategorized

Alere HIV Combo (4th Generation HIV Test)

You may read about the latest 4th generation rapid test Alere produces, here is some information about it.

Alere HIV Combo is a latest 4th generation HIV Test also known as HIV P24 Antigen Test.

It detects :

a) p24 antigen (Ag)

b) Antibodies (Ab) to HIV Type 1 and Type 2 (HIV-1 and HIV-2) in human whole blood.

The Benefit of this Alere HIV Combo test is it also test for HIV Antigen And Antibody Test.

How soon can p24 antigen be detected?

The p24 antigen test can detect the p24 protein on average 10 to 14 days after infection with HIV.  One drawback of this test is that levels of the p24 protein peak at around three to four weeks after exposure to HIV and are usually not detectable after five to six weeks (and sometimes even earlier).

Advantages:

  • This Alere HIV 4th generation hiv test accuracy is 100%
  • Rapid, accurate result in just 20 minutes
  • Easy to use – requires minimal training and no expensive lab equipment
  • It detects more acute infections compared to 2nd and 3rd generation tests which helps close the window period and enables increased case finding at a time when individuals are highly infectious

Knowledge:

What’s the difference between 4th and 3rd gen test kits?

Fourth-generation tests kits look for both antibodies AND antigens.

  • P24 Antigens are proteins on the surface of the HIV particle.
  • Antibodies are produced by the immune system in response to the HIV antigens. They fit together like a lock and key.

3rd generation tests take 6-8 weeks and only tests for antibodies.

4th generation tests are accurate 14 days after exposure, because this is when the p24 antigen becomes high enough to measure; effectively reducing the window period by average of 14 days.

A negative result at 28 days is good news but it is not conclusive. UK guidelines (BASHH) say that an early negative result at 28 days (1 month) needs to be confirmed with a second test 90 days (3 months) after the exposure.

Therefore, p24 antigen test window period is 14 days.

For more interpretation of results, watch this video below

Categories
HIV

Which is the genuine Prep HIV?

We Do NOT SELL PREP Medication

Do you know which is the genuine Prep HIV? Basically a lot of people don’t know how to differentiate which is the “real” and which is the “fake” hiv prep medication.

This is true, i’ve done a survey from Indian suppliers and here are informations i get from them.

Let’s look at the different packaging of each suppliers. Different packaging right?

One of these supplier told me A is selling fake Prep HIV medication. But wait a minute, i google the internet and i found India indeed have cases of fake medication.

Another source https://www.telegraphindia.com/states/bihar/snag-hits-war-on-fake-drugs-197244

That’s is why it’s important to consume the original real HIV PrEP (Pre-Exposure Prophylaxis) to avoid unnecessary side effects, horrible side effects.

If you get the real genuine ones, it doesn’t have any side effects.

How to know who is selling the genuine HIV Prep ones?

We Do NOT SELL PREP Medication